STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
fgfbp2aFibroblast growth factor-binding protein 2a. (215 aa)    
Predicted Functional Partners:
and2
Zgc:175106 protein.
   
  
 0.745
matn1
Matrilin 1.
   
  
 0.715
mia
Similar to cartilage-derived retinoic acid-sensitive protein.
      
 0.695
hmgn2
High mobility group nucleosomal-binding domain 2.
      
 0.690
ecrg4a
Augurin-A; Probable hormone (By similarity). Required for the proper formation of the central nervous system by attenuating cell proliferation during development.
   
  
 0.653
npffr1l2
Neuropeptide FF receptor 1 like 2; Belongs to the G-protein coupled receptor 1 family.
      
 0.644
c1qtnf5
C1q and tumor necrosis factor related protein 5.
   
  
 0.627
fgfbp1a
Fibroblast growth factor-binding protein 1b.
      
0.603
cilp2
Cartilage intermediate layer protein 2.
   
  
 0.602
htra1b
Serine protease HTRA1B; Serine protease with a variety of targets, including extracellular matrix proteins and proteoglycans. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF- beta family members. Consequently, may regulate many physiological processes. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets ( [...]
      
 0.552
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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