Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
gzmaGranzyme A; Belongs to the peptidase S1 family. (257 aa)    
Predicted Functional Partners:
casp8
Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.
    
 0.889
casp7
Caspase 7, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.
    
 0.839
tuba8l2
Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
    
  0.829
F2RL3
Si:ch211-132p1.2; Belongs to the G-protein coupled receptor 1 family.
    
 0.829
parp4
Poly [ADP-ribose] polymerase.
   
 
 0.814
parp1
Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.
   
  0.813
parp3
Poly [ADP-ribose] polymerase.
   
 
  0.811
parp2
Poly [ADP-ribose] polymerase.
   
  0.811
lmnl3
Lamin L3; Belongs to the intermediate filament family.
    
  0.809
lmnb1
Lamin B1; Belongs to the intermediate filament family.
    
  0.809
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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