Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
pttg1ipbPituitary tumor-transforming 1 interacting protein. (172 aa)    
Predicted Functional Partners:
pdzk1ip1
PDZK1-interacting protein 1.
      
 0.800
dexi
Dexamethasone-induced protein homolog; Belongs to the DEXI family.
      
 0.683
zbtb10
Zinc finger and BTB domain-containing 10.
      
 0.661
vti1b
Vesicle transport through interaction with t-SNAREs homolog 1B (Yeast).
    
   0.659
tp53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression.
    
   0.602
mxf
Myxovirus (influenza virus) resistance F; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
      
 0.595
march2
E3 ubiquitin-protein ligase MARCHF2; E3 ubiquitin-protein ligase which may be involved in endosomal trafficking. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.
      
 0.582
vamp8
Vesicle-associated membrane protein 8 (Endobrevin).
   
   0.571
stx8
Stx8 protein.
    
   0.559
tle3b
Transducin-like enhancer protein 3-B; Transcriptional corepressor that binds to a number of transcription factors; Belongs to the WD repeat Groucho/TLE family.
      
 0.546
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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