STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nek4NIMA-related kinase 4. (849 aa)    
Predicted Functional Partners:
rpgrip1l
RPGRIP1-like.
   
 
 0.795
tmem185
Transmembrane protein 185-like.
      
 0.744
spata7
Spermatogenesis-associated 7.
   
 
 0.697
txndc15
Interferon regulatory factor 1b.
    
 
 0.659
itih3b
Inter-alpha-trypsin inhibitor heavy chain 3b.
 
  
 
 0.649
nphp4
Si:dkey-202c5.1 protein.
   
 
 0.573
peak1
Pseudopodium-enriched atypical kinase 1.
      
 0.573
cmc2
COX assembly mitochondrial protein 2 homolog; May be involved in cytochrome c oxidase biogenesis. Belongs to the CMC family.
      
 0.565
eif4enif1
Eukaryotic translation initiation factor 4E nuclear import factor 1.
      
 0.552
sdccag8
Serologically defined colon cancer antigen 8 homolog; Plays a role in the establishment of cell polarity and epithelial lumen formation. Plays also an essential role in ciliogenesis and subsequent Hedgehog signaling pathway that requires the presence of intact primary cilia for pathway activation. Mechanistically, interacts with and mediates RABEP2 centrosomal localization which is critical for ciliogenesis (By similarity).
      
 0.552
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.