Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
krcpKelch repeat-containing protein. (537 aa)    
Predicted Functional Partners:
scml4
Scm polycomb group protein-like 4.
   
  
 0.817
znf367
Zinc finger protein 367; Transcriptional activator; Belongs to the krueppel C2H2-type zinc-finger protein family.
      
 0.720
glcci1a
Glucocorticoid-induced 1a.
      
 0.686
mex3a
RING-type domain-containing protein.
      
 0.680
apol1
Apolipoprotein L, 1.
    
 
 0.671
cbx1a
Chromobox homolog 1a (HP1 beta homolog Drosophila).
   
  
 0.670
dnmt3aa
DNA (cytosine-5-)-methyltransferase 3 alpha a; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
    
 
 0.612
cbx7a
Chromobox homolog 7a.
      
 0.594
skp1
S-phase kinase-associated protein 1A; Belongs to the SKP1 family.
    
 
 0.503
phc2a
Polyhomeotic-like protein 2; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (By similarity).
   
  
 0.465
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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