Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene co-occurrence
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[Homology]
Score
hormad1HORMA domain-containing protein 1; Plays a key role in meiotic progression by ensuring that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search, promoting synaptonemal- complex formation independently and playing key role in the male mid- pachytene checkpoint and the female meiotic prophase checkpoint. (356 aa)    
Predicted Functional Partners:
spo11
SPO11 initiator of meiotic double stranded breaks.
   
  
 0.940
trip13
Pachytene checkpoint protein 2 homolog; Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways (By similarity).
   
 
 0.931
ankrd31
Ankyrin repeat domain 31.
      
 0.875
rec114
REC114 meiotic recombination protein.
      
 0.837
tex11
Testis-expressed 11.
   
 
 0.835
LOC108192159
REC8 meiotic recombination protein a.
   
 
 0.832
dmc1
Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily.
   
 
 0.830
sycp3
Synaptonemal complex protein 3 like.
   
  
 0.793
smc1b
Structural maintenance of chromosomes protein.
   
 
 0.750
smc3
Structural maintenance of chromosomes protein.
    
 
 0.743
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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