Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
E7F063_DANRETyrosine-protein kinase. (480 aa)    
Predicted Functional Partners:
ENSDARP00000139721
Si:dkeyp-97a10.2.
    
  0.700
fundc1
FUN14 domain-containing protein 1; Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control; Belongs to the FUN14 family.
    
  0.532
fundc2
Fun14 domain-containing 2.
    
  0.532
mst1rb
Macrophage-stimulating 1 receptor b.
   
  0.504
mst1ra
Macrophage-stimulating 1 receptor a.
   
  0.504
met
MET proto-oncogene, receptor tyrosine kinase.
   
  0.504
pik3r3b
Phosphoinositide-3-kinase, regulatory subunit, polypeptide 3 (P55, gamma).
    
  0.478
pik3r1
Phosphoinositide-3-kinase, regulatory subunit 1 (alpha).
    
  0.478
pik3r2
Phosphoinositide-3-kinase, regulatory subunit 2 (beta).
    
  0.478
pik3r3a
Phosphoinositide-3-kinase, regulatory subunit 3a (gamma).
    
  0.478
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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