STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sox19bTranscription factor Sox-19b; Transcriptional activator. (293 aa)    
Predicted Functional Partners:
pou5f3
POU domain, class 5, transcription factor 1; Involved in early development of embryos, especially in the process of gastrulation. May play an important role in establishing and specifying rhombomeric segments. Seems to be required to maintain the cells in a highly undifferentiated state. In contrast to POU2, T-POU2 lacks DNA-binding activity because of its incomplete pou domain structure. Overexpression of POU2 does not have any effect on development, whereas overexpression of t-POU2 causes developmental retardation or arrest before gastrulation; Belongs to the POU transcription factor [...]
   
 
 0.882
nanog
Ovary-expressed homeobox protein.
   
  
 0.762
her3
Hairy-related 3.
   
  
 0.677
ctnnb1
Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...]
    
 0.625
dharma
Dharma.
   
 
 0.622
eif4g2a
Eukaryotic translation initiation factor 4, gamma 2a.
    
 
 0.621
sox4a-2
SRY-box transcription factor 4a.
   
  
 0.610
mxtx2
Mix-type homeobox gene 2.
   
 
 0.587
sox21a
Transcription factor Sox-21-A; May function as a switch in neuronal development (By similarity). Acts as a negative regulator of transcription. Plays a role in dorsoventral patterning of the embryo.
  
0.577
abtb2a
Ankyrin repeat and BTB (POZ) domain-containing 2a.
      
 0.566
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
Server load: low (32%) [HD]