node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
abtb2a | sox19b | ENSDARP00000077824 | ENSDARP00000058909 | Ankyrin repeat and BTB (POZ) domain-containing 2a. | Transcription factor Sox-19b; Transcriptional activator. | 0.566 |
ctnnb1 | dharma | ENSDARP00000139205 | ENSDARP00000060017 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | Dharma. | 0.713 |
ctnnb1 | nanog | ENSDARP00000139205 | ENSDARP00000102376 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | Ovary-expressed homeobox protein. | 0.472 |
ctnnb1 | pou5f3 | ENSDARP00000139205 | ENSDARP00000065816 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | POU domain, class 5, transcription factor 1; Involved in early development of embryos, especially in the process of gastrulation. May play an important role in establishing and specifying rhombomeric segments. Seems to be required to maintain the cells in a highly undifferentiated state. In contrast to POU2, T-POU2 lacks DNA-binding activity because of its incomplete pou domain structure. Overexpression of POU2 does not have any effect on development, whereas overexpression of t-POU2 causes developmental retardation or arrest before gastrulation; Belongs to the POU transcription factor [...] | 0.918 |
ctnnb1 | sox19b | ENSDARP00000139205 | ENSDARP00000058909 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | Transcription factor Sox-19b; Transcriptional activator. | 0.625 |
ctnnb1 | sox21a | ENSDARP00000139205 | ENSDARP00000049338 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | Transcription factor Sox-21-A; May function as a switch in neuronal development (By similarity). Acts as a negative regulator of transcription. Plays a role in dorsoventral patterning of the embryo. | 0.605 |
dharma | ctnnb1 | ENSDARP00000060017 | ENSDARP00000139205 | Dharma. | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | 0.713 |
dharma | sox19b | ENSDARP00000060017 | ENSDARP00000058909 | Dharma. | Transcription factor Sox-19b; Transcriptional activator. | 0.622 |
eif4g2a | mxtx2 | ENSDARP00000017878 | ENSDARP00000025485 | Eukaryotic translation initiation factor 4, gamma 2a. | Mix-type homeobox gene 2. | 0.832 |
eif4g2a | sox19b | ENSDARP00000017878 | ENSDARP00000058909 | Eukaryotic translation initiation factor 4, gamma 2a. | Transcription factor Sox-19b; Transcriptional activator. | 0.621 |
her3 | sox19b | ENSDARP00000099080 | ENSDARP00000058909 | Hairy-related 3. | Transcription factor Sox-19b; Transcriptional activator. | 0.677 |
her3 | sox21a | ENSDARP00000099080 | ENSDARP00000049338 | Hairy-related 3. | Transcription factor Sox-21-A; May function as a switch in neuronal development (By similarity). Acts as a negative regulator of transcription. Plays a role in dorsoventral patterning of the embryo. | 0.455 |
mxtx2 | eif4g2a | ENSDARP00000025485 | ENSDARP00000017878 | Mix-type homeobox gene 2. | Eukaryotic translation initiation factor 4, gamma 2a. | 0.832 |
mxtx2 | nanog | ENSDARP00000025485 | ENSDARP00000102376 | Mix-type homeobox gene 2. | Ovary-expressed homeobox protein. | 0.758 |
mxtx2 | pou5f3 | ENSDARP00000025485 | ENSDARP00000065816 | Mix-type homeobox gene 2. | POU domain, class 5, transcription factor 1; Involved in early development of embryos, especially in the process of gastrulation. May play an important role in establishing and specifying rhombomeric segments. Seems to be required to maintain the cells in a highly undifferentiated state. In contrast to POU2, T-POU2 lacks DNA-binding activity because of its incomplete pou domain structure. Overexpression of POU2 does not have any effect on development, whereas overexpression of t-POU2 causes developmental retardation or arrest before gastrulation; Belongs to the POU transcription factor [...] | 0.490 |
mxtx2 | sox19b | ENSDARP00000025485 | ENSDARP00000058909 | Mix-type homeobox gene 2. | Transcription factor Sox-19b; Transcriptional activator. | 0.587 |
nanog | ctnnb1 | ENSDARP00000102376 | ENSDARP00000139205 | Ovary-expressed homeobox protein. | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | 0.472 |
nanog | mxtx2 | ENSDARP00000102376 | ENSDARP00000025485 | Ovary-expressed homeobox protein. | Mix-type homeobox gene 2. | 0.758 |
nanog | pou5f3 | ENSDARP00000102376 | ENSDARP00000065816 | Ovary-expressed homeobox protein. | POU domain, class 5, transcription factor 1; Involved in early development of embryos, especially in the process of gastrulation. May play an important role in establishing and specifying rhombomeric segments. Seems to be required to maintain the cells in a highly undifferentiated state. In contrast to POU2, T-POU2 lacks DNA-binding activity because of its incomplete pou domain structure. Overexpression of POU2 does not have any effect on development, whereas overexpression of t-POU2 causes developmental retardation or arrest before gastrulation; Belongs to the POU transcription factor [...] | 0.984 |
nanog | sox19b | ENSDARP00000102376 | ENSDARP00000058909 | Ovary-expressed homeobox protein. | Transcription factor Sox-19b; Transcriptional activator. | 0.762 |