Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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rx2Retinal homeobox protein Rx2; Plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation; Belongs to the paired homeobox family. Bicoid subfamily. (327 aa)    
Predicted Functional Partners:
six6b
Sine oculis-related homeobox 6b.
   
 
 0.664
six3b
Sine oculis homeobox homolog 3b.
   
 
 0.581
atoh7
Protein atonal homolog 7; Transcription factor involved in the differentiation of retinal ganglion cells.
      
 0.578
waca
WW domain-containing adapter protein with coiled-coil; Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1). Positive regulator of amino acid starvation-induced autophagy. Positively regulates MTOR activity. May negatively regulate the ubiquitin proteasome pathway.
      
 0.569
pax2a
Paired box protein Pax-2a; Probable transcription factor involved in the development of the midbrain/hindbrain boundary (MHB) organizer and specification of neuronal cell fates. Required for establishment of eng2 and eng3 gene expression in the midbrain and MHB primordium during late gastrulation.
   
 
 0.530
ap1m3
Adaptor-related protein complex 1 subunit mu 3; Belongs to the adaptor complexes medium subunit family.
    
 
 0.529
ap1m1
AP-1 complex subunit mu-1; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
    
 
 0.529
myl7
Myosin, light polypeptide 7, regulatory.
    
 
 0.526
gnat2
Guanine nucleotide-binding protein (G protein), alpha transducing activity polypeptide 2.
   
  
 0.503
zpr1
ZPR1 zinc finger.
      
 0.485
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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