Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-expression
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[Homology]
Score
irf2Interferon regulatory factor 2. (256 aa)    
Predicted Functional Partners:
irf2bp1
Interferon regulatory factor 2-binding protein 1; Acts as a transcriptional repressor; Belongs to the IRF2BP family.
    
 
 0.951
irf2bp2b
Interferon regulatory factor 2-binding protein 2-B; Acts as a transcriptional repressor; Belongs to the IRF2BP family.
    
 
 0.942
irf2bpl
Interferon regulatory factor 2-binding protein-like.
    
 
 0.908
irf2bp2a
Interferon regulatory factor 2-binding protein 2-A; Acts as a transcriptional repressor; Belongs to the IRF2BP family.
    
 
 0.871
irf1b
Interferon regulatory factor.
  
 
0.808
traf6
TNF receptor-associated factor 6; E3 ubiquitin-protein ligase that mediates ubiquitination of proteins. Adapter protein that seems to play a role in signal transduction.
    
 0.780
rfc3
Replication factor C (Activator 1) 3.
   
 
 0.767
pcna
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.
   
 
 0.733
stat1a
Signal transducer and activator of transcription.
    
 0.646
ifnphi1
Interferon phi 1.
     
 0.646
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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