STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
epcamEpithelial cell adhesion molecule. (303 aa)    
Predicted Functional Partners:
cldnb
Cldnb protein.
   
 
 0.747
cldn7a
Claudin-7-A; Plays a major role in tight junction-specific obliteration of the intercellular space; Belongs to the claudin family.
   
 
 0.677
cldn1
Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.
   
 
 0.610
cxadr
Coxsackievirus and adenovirus receptor homolog; May function as a homophilic cell adhesion molecule and be essential for tight junction integrity. May also be involved in transepithelial migration of leukocytes through adhesive interactions with jaml. The interaction between both receptors may also mediate the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair (By similarity).
   
  
 0.609
spint1a
Serine peptidase inhibitor, Kunitz type 1 a.
   
  
 0.593
cldn7b
Claudin-7-B; Plays a major role in tight junction-specific obliteration of the intercellular space; Belongs to the claudin family.
   
 
 0.588
pdzk1ip1
PDZK1-interacting protein 1.
      
 0.541
shroom2a
Shroom family member 2a.
      
 0.540
cd9b
Tetraspanin.
   
  
 0.531
s100t
Protein S100; Belongs to the S-100 family.
  
  
 0.499
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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