Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
spsb4bSplA/ryanodine receptor domain and SOCS box-containing 4b. (281 aa)    
Predicted Functional Partners:
eloca
Elongin C paralog a; Belongs to the SKP1 family.
   
  0.729
cul5a
Cullin 5a; Belongs to the cullin family.
    
  0.720
spsb3a
SplA/ryanodine receptor domain and SOCS box-containing 3a.
     
0.628
mycbp2
E3 ubiquitin-protein ligase MYCBP2; Atypical E3 ubiquitin-protein ligase which specifically mediates ubiquitination of threonine and serine residues on target proteins, instead of ubiquitinating lysine residues (By similarity). Shows esterification activity towards both threonine and serine, with a preference for threonine, and acts via two essential catalytic cysteine residues that relay ubiquitin to its substrate via thioester intermediates (By similarity). Interacts with the E2 enzymes UBE2D1, UBE2D3, UBE2E1 and UBE2L3 (By similarity). Plays a key role in neural development, probabl [...]
    
 
 0.589
rnf7
Ring finger protein 7.
    
 0.569
elocb
Elongin C paralog b; Belongs to the SKP1 family.
    
   0.556
cul5b
Cullin 5b; Belongs to the cullin family.
    
   0.554
ttc1
Tetratricopeptide repeat domain 1.
    
   0.532
commd2
COMM domain-containing 2.
   
 
  0.529
skp1
S-phase kinase-associated protein 1A; Belongs to the SKP1 family.
   
   0.524
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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