Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
rad1RAD1 homolog (S. pombe). (279 aa)    
Predicted Functional Partners:
rad9a
Cell cycle checkpoint control protein; Belongs to the rad9 family.
   
 0.999
rad9b
Cell cycle checkpoint control protein; Belongs to the rad9 family.
    
 0.999
HUS1B
Checkpoint protein; Belongs to the HUS1 family.
    
 0.999
rad17
RAD17 checkpoint clamp loader component.
   
 0.998
atr
ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.
    
 0.994
E7F2N1_DANRE
Si:ch73-352p4.5.
   
 0.987
rfc4
Replication factor C (activator 1) 4.
   
 0.983
zbtb14
Zinc finger and BTB domain-containing 14.
    
   0.967
topbp1
DNA topoisomerase II-binding protein 1.
   
 0.962
rpa1
Replication protein A 70 kDa DNA-binding subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.
   
 0.952
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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