Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
rtf2Replication termination factor 2. (310 aa)    
Predicted Functional Partners:
trmt1
tRNA methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
    
   0.890
yars1
Tyrosine--tRNA ligase, cytoplasmic; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
    
   0.880
rtf1
RTF1 homolog, Paf1/RNA polymerase II complex component.
      
 0.862
zfand4
Zinc finger, AN1-type domain 4.
      
 0.744
pafah1b2
Platelet-activating factor acetylhydrolase 1b, catalytic subunit 2.
      
 0.720
rpl35
60S ribosomal protein L35; Plays an essential role in early embryonic development. May act as a haploinsufficient tumor suppressor. Belongs to the universal ribosomal protein uL29 family.
      
 0.695
spaca9
Sperm acrosome-associated 9.
      
 0.692
ccdc130
Coiled-coil domain-containing protein 130 homolog; Belongs to the CWC16 family.
      
 0.606
rnf17
Ring finger protein 17.
      
 0.606
TOM1L2
Target of myb1 like 2 membrane trafficking protein; Belongs to the TOM1 family.
      
 0.597
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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