Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
lrrc32Leucine-rich repeat-containing 32. (659 aa)    
Predicted Functional Partners:
tgfb3
Transforming growth factor beta; Belongs to the TGF-beta family.
    
 0.990
tgfb1a
Transforming growth factor beta; Belongs to the TGF-beta family.
    
 0.988
tgfb1b
Transforming growth factor beta; Belongs to the TGF-beta family.
    
 0.988
nrros
Transforming growth factor beta activator LRRC33; Key regulator of transforming growth factor beta-1 (TGFB1) specifically required for microglia function in the nervous system. Required for activation of latent TGF-beta-1 in macrophages and microglia: associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGFB1, and regulates integrin-dependent activation of TGF-beta-1. TGF- beta-1 activation mediated by lrrc33/nrros is highly localized: there is little spreading of TGF-beta-1 activated from one microglial cell to neighbo [...]
  
  
0.951
tgfb5
Transforming growth factor beta; Belongs to the TGF-beta family.
    
 0.924
tgfb2
Transforming growth factor, beta 2.
    
 0.924
dcbld2
Discoidin, CUB and LCCL domain-containing 2.
      
 0.892
med22
Mediator of RNA polymerase II transcription subunit 22; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
   
  
 0.781
lrrc31
Leucine-rich repeat-containing 31.
    
 0.730
rabep1
Rabaptin, RAB GTPase-binding effector protein 1.
      
 0.704
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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