STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
nab1bNGFI-A-binding protein 1b (EGR1 binding protein 1). (500 aa)    
Predicted Functional Partners:
cd99l2
CD99 antigen-like protein 2; May function as a homophilic adhesion molecule. Belongs to the CD99 family.
      
 0.743
egr1
Early growth response protein 1; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status (By similarity). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Mediates responses to ischemia and hypoxia; regulates the express [...]
    
 
 0.734
egr3
Early growth response 3.
    
 
 0.734
vgll3
Vestigial-like family member 3.
      
 0.720
znf362a
Zinc finger protein 362a.
    
 
 0.694
znf362b
Zinc finger protein 362b.
    
 
 0.694
znf384l
Novel protein similar to vertebrate zinc finger protein 384 (ZNF384).
    
 
 0.694
nab2
NGFI-A-binding protein 2 (EGR1 binding protein 2).
   
 
 0.662
egr2b
Early growth response protein 2b; Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4.
    
 
 0.657
aktip
AKT-interacting protein; May function to promote vesicle trafficking and/or fusion. May also regulate apoptosis (By similarity).
    
   0.611
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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