Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
fgf14Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (248 aa)    
Predicted Functional Partners:
fgf23
Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family.
   
  
 0.681
fgf18b
Fibroblast growth factor 18b; Belongs to the heparin-binding growth factors family.
   
  
 0.669
fgf24
Fibroblast growth factor; Belongs to the heparin-binding growth factors family.
      
 0.634
fgfr3
Fibroblast growth factor receptor 3; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Phosphorylates PLCG1, CBL and FRS2. Ligand binding l [...]
    
 0.626
fgf18a
Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family.
      
 0.592
LOC100001991
ADAM metallopeptidase with thrombospondin type 1 motif, 15b.
   
  
 0.592
fgf21
Fibroblast growth factor 21; Belongs to the heparin-binding growth factors family.
      
 0.589
LOC100002059
ADAM metallopeptidase with thrombospondin type 1 motif, 15b.
   
  
 0.588
igsf9b
Immunoglobulin superfamily, member 9b.
      
 0.566
nacad
NAC alpha domain-containing.
      
 0.562
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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