Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
hspb1Heat shock protein, alpha-crystallin-related, 1; Belongs to the small heat shock protein (HSP20) family. (199 aa)    
Predicted Functional Partners:
mapkapk2a
Mitogen-activated protein kinase-activated protein kinase 2a; Belongs to the protein kinase superfamily.
   
 0.995
mapkapk3
MAPK-activated protein kinase 3; Belongs to the protein kinase superfamily.
    
 0.995
mapkapk5
Mitogen-activated protein kinase-activated protein kinase 5.
    
 0.994
mapkapk2b
MAPK-activated protein kinase 2b; Belongs to the protein kinase superfamily.
    
 0.975
hspa8
Heat shock cognate 71 kDa protein; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis a [...]
   
 0.963
cryaba
Crystallin, alpha B, a; Belongs to the small heat shock protein (HSP20) family.
   
0.943
hsp70.3
Heat shock cognate 70-kd protein, tandem duplicate 3; Belongs to the heat shock protein 70 family.
   
 0.928
hsp70.1
Heat shock cognate 70-kd protein, tandem duplicate 1; Belongs to the heat shock protein 70 family.
   
 0.922
bag3
BCL2-associated athanogene 3.
   
 
 0.911
hsp70.2
Heat shock cognate 70-kd protein, tandem duplicate 2; Belongs to the heat shock protein 70 family.
   
 0.896
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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