node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
RSBN1 | kmt5aa | ENSDARP00000136548 | ENSDARP00000140543 | Round spermatid basic protein 1. | N-lysine methyltransferase KMT5A-A; Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and prope [...] | 0.758 |
RSBN1 | kmt5b | ENSDARP00000136548 | ENSDARP00000060190 | Round spermatid basic protein 1. | Histone-lysine N-methyltransferase KMT5B; Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity. In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes (By similarity). H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromat [...] | 0.768 |
RSBN1 | phf2 | ENSDARP00000136548 | ENSDARP00000045941 | Round spermatid basic protein 1. | Lysine-specific demethylase phf2; Lysine demethylase that demethylates both histones and non- histone proteins. Mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2). Recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA (By similarity). | 0.675 |
ash1l | dot1l | ENSDARP00000105655 | ENSDARP00000083509 | Ash1 (absent, small, or homeotic)-like (Drosophila). | Histone-lysine N-methyltransferase, H3 lysine-79 specific. | 0.629 |
ash1l | kmt5b | ENSDARP00000105655 | ENSDARP00000060190 | Ash1 (absent, small, or homeotic)-like (Drosophila). | Histone-lysine N-methyltransferase KMT5B; Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity. In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes (By similarity). H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromat [...] | 0.816 |
ash1l | nsd2 | ENSDARP00000105655 | ENSDARP00000002944 | Ash1 (absent, small, or homeotic)-like (Drosophila). | Nuclear receptor-binding SET domain protein 2. | 0.769 |
ash1l | nsd3 | ENSDARP00000105655 | ENSDARP00000151686 | Ash1 (absent, small, or homeotic)-like (Drosophila). | Nuclear receptor-binding SET domain protein 3. | 0.580 |
ash1l | setd2 | ENSDARP00000105655 | ENSDARP00000114457 | Ash1 (absent, small, or homeotic)-like (Drosophila). | SET domain-containing 2, histone lysine methyltransferase. | 0.869 |
dot1l | ash1l | ENSDARP00000083509 | ENSDARP00000105655 | Histone-lysine N-methyltransferase, H3 lysine-79 specific. | Ash1 (absent, small, or homeotic)-like (Drosophila). | 0.629 |
dot1l | ehmt2 | ENSDARP00000083509 | ENSDARP00000130049 | Histone-lysine N-methyltransferase, H3 lysine-79 specific. | Euchromatic histone-lysine N-methyltransferase 2. | 0.749 |
dot1l | kmt5aa | ENSDARP00000083509 | ENSDARP00000140543 | Histone-lysine N-methyltransferase, H3 lysine-79 specific. | N-lysine methyltransferase KMT5A-A; Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and prope [...] | 0.545 |
dot1l | kmt5b | ENSDARP00000083509 | ENSDARP00000060190 | Histone-lysine N-methyltransferase, H3 lysine-79 specific. | Histone-lysine N-methyltransferase KMT5B; Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity. In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes (By similarity). H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromat [...] | 0.720 |
dot1l | nsd2 | ENSDARP00000083509 | ENSDARP00000002944 | Histone-lysine N-methyltransferase, H3 lysine-79 specific. | Nuclear receptor-binding SET domain protein 2. | 0.573 |
dot1l | nsd3 | ENSDARP00000083509 | ENSDARP00000151686 | Histone-lysine N-methyltransferase, H3 lysine-79 specific. | Nuclear receptor-binding SET domain protein 3. | 0.673 |
dot1l | phf2 | ENSDARP00000083509 | ENSDARP00000045941 | Histone-lysine N-methyltransferase, H3 lysine-79 specific. | Lysine-specific demethylase phf2; Lysine demethylase that demethylates both histones and non- histone proteins. Mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2). Recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA (By similarity). | 0.491 |
dot1l | setd2 | ENSDARP00000083509 | ENSDARP00000114457 | Histone-lysine N-methyltransferase, H3 lysine-79 specific. | SET domain-containing 2, histone lysine methyltransferase. | 0.842 |
dot1l | suv39h1a | ENSDARP00000083509 | ENSDARP00000034818 | Histone-lysine N-methyltransferase, H3 lysine-79 specific. | Histone-lysine N-methyltransferase SUV39H1-A; Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric [...] | 0.621 |
ehmt2 | dot1l | ENSDARP00000130049 | ENSDARP00000083509 | Euchromatic histone-lysine N-methyltransferase 2. | Histone-lysine N-methyltransferase, H3 lysine-79 specific. | 0.749 |
ehmt2 | kmt5b | ENSDARP00000130049 | ENSDARP00000060190 | Euchromatic histone-lysine N-methyltransferase 2. | Histone-lysine N-methyltransferase KMT5B; Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity. In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes (By similarity). H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromat [...] | 0.752 |
ehmt2 | nsd3 | ENSDARP00000130049 | ENSDARP00000151686 | Euchromatic histone-lysine N-methyltransferase 2. | Nuclear receptor-binding SET domain protein 3. | 0.585 |