| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| cyp26a1 | cyp27c1 | ENSDARP00000041727 | ENSDARP00000118349 | Cytochrome P450 26A1; A cytochrome P450 monooxygenase involved in the metabolism of all-trans retinoic acid (atRA), a signaling molecule that binds to retinoic acid receptors and regulates gene transcription. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds of atRA primarily at C-4. Has no activity toward 9-cis and 13-cis retinoic acid stereoisomer [...] | Cytochrome P450 27C1; Efficiently catalyzes the conversion of all-trans retinol (also called vitamin A1, the precursor of 11-cis retinal) to 3,4- didehydroretinol (also called vitamin A2, the precursor of 11-cis 3,4- didehydroretinal). Also acts on all-trans retinal and all-trans retinoic acid. The replacement of 11-cis retinal chromophore in photopigments with 11-cis 3,4-didehydroretinal enhances sensitivity to long-wavelength light. This may improve vision in fresh water which is often turbid; Belongs to the cytochrome P450 family. | 0.970 |
| cyp26a1 | dgat1a | ENSDARP00000041727 | ENSDARP00000137795 | Cytochrome P450 26A1; A cytochrome P450 monooxygenase involved in the metabolism of all-trans retinoic acid (atRA), a signaling molecule that binds to retinoic acid receptors and regulates gene transcription. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds of atRA primarily at C-4. Has no activity toward 9-cis and 13-cis retinoic acid stereoisomer [...] | O-acyltransferase. | 0.961 |
| cyp26a1 | dhrs13a.3 | ENSDARP00000041727 | ENSDARP00000060303 | Cytochrome P450 26A1; A cytochrome P450 monooxygenase involved in the metabolism of all-trans retinoic acid (atRA), a signaling molecule that binds to retinoic acid receptors and regulates gene transcription. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds of atRA primarily at C-4. Has no activity toward 9-cis and 13-cis retinoic acid stereoisomer [...] | Dehydrogenase/reductase (SDR family) member 13a, duplicate 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.598 |
| cyp26a1 | lrata | ENSDARP00000041727 | ENSDARP00000054227 | Cytochrome P450 26A1; A cytochrome P450 monooxygenase involved in the metabolism of all-trans retinoic acid (atRA), a signaling molecule that binds to retinoic acid receptors and regulates gene transcription. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds of atRA primarily at C-4. Has no activity toward 9-cis and 13-cis retinoic acid stereoisomer [...] | Lecithin retinol acyltransferase a. | 0.965 |
| cyp26a1 | lratb.1 | ENSDARP00000041727 | ENSDARP00000075023 | Cytochrome P450 26A1; A cytochrome P450 monooxygenase involved in the metabolism of all-trans retinoic acid (atRA), a signaling molecule that binds to retinoic acid receptors and regulates gene transcription. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds of atRA primarily at C-4. Has no activity toward 9-cis and 13-cis retinoic acid stereoisomer [...] | Lecithin retinol acyltransferase b, tandem duplicate 1. | 0.952 |
| cyp26a1 | pnpla4 | ENSDARP00000041727 | ENSDARP00000100462 | Cytochrome P450 26A1; A cytochrome P450 monooxygenase involved in the metabolism of all-trans retinoic acid (atRA), a signaling molecule that binds to retinoic acid receptors and regulates gene transcription. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds of atRA primarily at C-4. Has no activity toward 9-cis and 13-cis retinoic acid stereoisomer [...] | Patatin-like phospholipase domain-containing 4. | 0.952 |
| cyp27c1 | cyp26a1 | ENSDARP00000118349 | ENSDARP00000041727 | Cytochrome P450 27C1; Efficiently catalyzes the conversion of all-trans retinol (also called vitamin A1, the precursor of 11-cis retinal) to 3,4- didehydroretinol (also called vitamin A2, the precursor of 11-cis 3,4- didehydroretinal). Also acts on all-trans retinal and all-trans retinoic acid. The replacement of 11-cis retinal chromophore in photopigments with 11-cis 3,4-didehydroretinal enhances sensitivity to long-wavelength light. This may improve vision in fresh water which is often turbid; Belongs to the cytochrome P450 family. | Cytochrome P450 26A1; A cytochrome P450 monooxygenase involved in the metabolism of all-trans retinoic acid (atRA), a signaling molecule that binds to retinoic acid receptors and regulates gene transcription. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds of atRA primarily at C-4. Has no activity toward 9-cis and 13-cis retinoic acid stereoisomer [...] | 0.970 |
| cyp27c1 | dgat1a | ENSDARP00000118349 | ENSDARP00000137795 | Cytochrome P450 27C1; Efficiently catalyzes the conversion of all-trans retinol (also called vitamin A1, the precursor of 11-cis retinal) to 3,4- didehydroretinol (also called vitamin A2, the precursor of 11-cis 3,4- didehydroretinal). Also acts on all-trans retinal and all-trans retinoic acid. The replacement of 11-cis retinal chromophore in photopigments with 11-cis 3,4-didehydroretinal enhances sensitivity to long-wavelength light. This may improve vision in fresh water which is often turbid; Belongs to the cytochrome P450 family. | O-acyltransferase. | 0.945 |
| cyp27c1 | dhrs13a.3 | ENSDARP00000118349 | ENSDARP00000060303 | Cytochrome P450 27C1; Efficiently catalyzes the conversion of all-trans retinol (also called vitamin A1, the precursor of 11-cis retinal) to 3,4- didehydroretinol (also called vitamin A2, the precursor of 11-cis 3,4- didehydroretinal). Also acts on all-trans retinal and all-trans retinoic acid. The replacement of 11-cis retinal chromophore in photopigments with 11-cis 3,4-didehydroretinal enhances sensitivity to long-wavelength light. This may improve vision in fresh water which is often turbid; Belongs to the cytochrome P450 family. | Dehydrogenase/reductase (SDR family) member 13a, duplicate 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.595 |
| cyp27c1 | lrata | ENSDARP00000118349 | ENSDARP00000054227 | Cytochrome P450 27C1; Efficiently catalyzes the conversion of all-trans retinol (also called vitamin A1, the precursor of 11-cis retinal) to 3,4- didehydroretinol (also called vitamin A2, the precursor of 11-cis 3,4- didehydroretinal). Also acts on all-trans retinal and all-trans retinoic acid. The replacement of 11-cis retinal chromophore in photopigments with 11-cis 3,4-didehydroretinal enhances sensitivity to long-wavelength light. This may improve vision in fresh water which is often turbid; Belongs to the cytochrome P450 family. | Lecithin retinol acyltransferase a. | 0.963 |
| cyp27c1 | lratb.1 | ENSDARP00000118349 | ENSDARP00000075023 | Cytochrome P450 27C1; Efficiently catalyzes the conversion of all-trans retinol (also called vitamin A1, the precursor of 11-cis retinal) to 3,4- didehydroretinol (also called vitamin A2, the precursor of 11-cis 3,4- didehydroretinal). Also acts on all-trans retinal and all-trans retinoic acid. The replacement of 11-cis retinal chromophore in photopigments with 11-cis 3,4-didehydroretinal enhances sensitivity to long-wavelength light. This may improve vision in fresh water which is often turbid; Belongs to the cytochrome P450 family. | Lecithin retinol acyltransferase b, tandem duplicate 1. | 0.943 |
| cyp27c1 | pnpla4 | ENSDARP00000118349 | ENSDARP00000100462 | Cytochrome P450 27C1; Efficiently catalyzes the conversion of all-trans retinol (also called vitamin A1, the precursor of 11-cis retinal) to 3,4- didehydroretinol (also called vitamin A2, the precursor of 11-cis 3,4- didehydroretinal). Also acts on all-trans retinal and all-trans retinoic acid. The replacement of 11-cis retinal chromophore in photopigments with 11-cis 3,4-didehydroretinal enhances sensitivity to long-wavelength light. This may improve vision in fresh water which is often turbid; Belongs to the cytochrome P450 family. | Patatin-like phospholipase domain-containing 4. | 0.950 |
| dgat1a | cyp26a1 | ENSDARP00000137795 | ENSDARP00000041727 | O-acyltransferase. | Cytochrome P450 26A1; A cytochrome P450 monooxygenase involved in the metabolism of all-trans retinoic acid (atRA), a signaling molecule that binds to retinoic acid receptors and regulates gene transcription. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds of atRA primarily at C-4. Has no activity toward 9-cis and 13-cis retinoic acid stereoisomer [...] | 0.961 |
| dgat1a | cyp27c1 | ENSDARP00000137795 | ENSDARP00000118349 | O-acyltransferase. | Cytochrome P450 27C1; Efficiently catalyzes the conversion of all-trans retinol (also called vitamin A1, the precursor of 11-cis retinal) to 3,4- didehydroretinol (also called vitamin A2, the precursor of 11-cis 3,4- didehydroretinal). Also acts on all-trans retinal and all-trans retinoic acid. The replacement of 11-cis retinal chromophore in photopigments with 11-cis 3,4-didehydroretinal enhances sensitivity to long-wavelength light. This may improve vision in fresh water which is often turbid; Belongs to the cytochrome P450 family. | 0.945 |
| dgat1a | dhrs13a.3 | ENSDARP00000137795 | ENSDARP00000060303 | O-acyltransferase. | Dehydrogenase/reductase (SDR family) member 13a, duplicate 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.621 |
| dgat1a | lrata | ENSDARP00000137795 | ENSDARP00000054227 | O-acyltransferase. | Lecithin retinol acyltransferase a. | 0.922 |
| dgat1a | lratb.1 | ENSDARP00000137795 | ENSDARP00000075023 | O-acyltransferase. | Lecithin retinol acyltransferase b, tandem duplicate 1. | 0.920 |
| dgat1a | pnpla4 | ENSDARP00000137795 | ENSDARP00000100462 | O-acyltransferase. | Patatin-like phospholipase domain-containing 4. | 0.950 |
| dhrs13a.3 | cyp26a1 | ENSDARP00000060303 | ENSDARP00000041727 | Dehydrogenase/reductase (SDR family) member 13a, duplicate 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Cytochrome P450 26A1; A cytochrome P450 monooxygenase involved in the metabolism of all-trans retinoic acid (atRA), a signaling molecule that binds to retinoic acid receptors and regulates gene transcription. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds of atRA primarily at C-4. Has no activity toward 9-cis and 13-cis retinoic acid stereoisomer [...] | 0.598 |
| dhrs13a.3 | cyp27c1 | ENSDARP00000060303 | ENSDARP00000118349 | Dehydrogenase/reductase (SDR family) member 13a, duplicate 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Cytochrome P450 27C1; Efficiently catalyzes the conversion of all-trans retinol (also called vitamin A1, the precursor of 11-cis retinal) to 3,4- didehydroretinol (also called vitamin A2, the precursor of 11-cis 3,4- didehydroretinal). Also acts on all-trans retinal and all-trans retinoic acid. The replacement of 11-cis retinal chromophore in photopigments with 11-cis 3,4-didehydroretinal enhances sensitivity to long-wavelength light. This may improve vision in fresh water which is often turbid; Belongs to the cytochrome P450 family. | 0.595 |
