Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
aagabAlpha and gamma adaptin-binding protein. (321 aa)    
Predicted Functional Partners:
ap2s1
AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.
    
 
 0.988
ccdc32
Coiled-coil domain-containing 32.
    
   0.940
ap2a1
AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]
    
 
 0.928
ap1g1
AP-1 complex subunit gamma.
    
 
 0.909
ap1s1
AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.
   
 
 0.898
arfgap1
ADP-ribosylation factor GTPase-activating protein 1.
    
   0.848
ap1g2
AP-1 complex subunit gamma.
    
 
 0.775
mfsd9
Major facilitator superfamily domain-containing 9.
      
 0.739
exoc5
Exocyst complex component 5.
      
 0.696
ccdc115
Coiled-coil domain-containing protein 115; Accessory component of the proton-transporting vacuolar (V)- ATPase protein pump involved in intracellular iron homeostasis. May be involved in Golgi homeostasis.
      
 0.617
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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