Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
crygm5Crystallin, gamma M5; Belongs to the beta/gamma-crystallin family. (177 aa)    
Predicted Functional Partners:
mhc1lfa
Major histocompatibility complex class I LFA.
      
 0.885
lenep
Lens epithelial protein.
      
 0.815
guca1b
Guanylate cyclase-activating protein 2.
   
  
 0.574
guca1a
Guanylate cyclase activator 1A.
      
 0.572
grk7b
Rhodopsin kinase grk7-b; Retina-specific kinase involved in the shutoff of the photoresponse and adaptation to changing light conditions via cone opsin phosphorylation, including rhodopsin (RHO).
      
 0.564
rgra
Retinal pigment epithelium retinal G protein receptor-1.
      
 0.561
rpe65b
All-trans-retinyl ester 13-cis isomerohydrolase; Specifically generates 13-cis retinol, a stereoisomeric form of retinoic acid. Capable of catalyzing the isomerization of lutein to meso-zeaxanthin an eye-specific carotenoid (By similarity).
      
 0.554
cryaa
Crystallin, alpha A; Belongs to the small heat shock protein (HSP20) family.
   
  
 0.484
gucy2d
Guanylate cyclase.
      
 0.464
serpinh1b
Serpin peptidase inhibitor, clade H (heat shock protein 47), member 1b; Belongs to the serpin family.
      
 0.461
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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