Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
cetn4Centrin 4. (171 aa)    
Predicted Functional Partners:
sfi1
SFI1 centrin-binding protein.
    
 
 0.931
xpc
Xeroderma pigmentosum, complementation group C.
    
 0.908
poc5
POC5 centriolar protein homolog (Chlamydomonas).
    
 
 0.899
gtf2h3
General transcription factor IIH, polypeptide 3.
    
 0.825
ercc3
General transcription and DNA repair factor IIH helicase subunit XPB; ATP-dependent 3'-5' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATPase activity of XPB/ERCC3, but not its helicase activity, is required fo [...]
    
 0.821
gtf2h5
General transcription factor IIH, polypeptide 5.
   
 0.813
cfap43
Cilia and flagella-associated protein 43.
    
 
 0.810
xpa
Xeroderma pigmentosum, complementation group A.
    
 0.790
wdr90
WD repeat domain 90.
    
 
 0.788
rad23aa
RAD23 homolog A, nucleotide excision repair protein a.
   
 0.780
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
Server load: medium (42%) [HD]