STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
lgi3Leucine-rich repeat LGI family, member 3. (551 aa)    
Predicted Functional Partners:
adam22
ADAM metallopeptidase domain 22.
     
 0.864
got1l1
Glutamic-oxaloacetic transaminase 1-like 1.
      
 0.814
adam23a
ADAM metallopeptidase domain 23a.
     
 0.723
epb41l3a
Erythrocyte membrane protein band 4.1-like 3a.
      
 0.690
lrrc7
Leucine-rich repeat-containing 7.
    
 
 0.677
arl4d
ADP-ribosylation factor-like 4D.
    
 
 0.671
trabd2b
Metalloprotease TIKI2; Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation (By similarity).
      
 0.669
fgf17
Fibroblast growth factor 17; Involved in dorsal-ventral embryonic patterning, by promoting expression of bone morphogenetic protein (BMP) antagonists such as chd. Also involved in anterior-posterior neural patterning and in mesoderm induction; Belongs to the heparin-binding growth factors family.
    
 
 0.600
sorbs3
Sorbin and SH3 domain-containing 3.
   
  
 0.587
dmtn
Dematin actin-binding protein.
      
 0.571
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.