Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
eif2b2Eukaryotic translation initiation factor 2B, subunit 2 beta; Belongs to the eIF-2B alpha/beta/delta subunits family. (355 aa)    
Predicted Functional Partners:
eif2b1
Eukaryotic translation initiation factor 2B, subunit 1 alpha; Belongs to the eIF-2B alpha/beta/delta subunits family.
  
0.999
eif2b3
Eukaryotic translation initiation factor 2B, subunit 3 gamma.
   
 0.999
eif2b5
Eukaryotic translation initiation factor 2B, subunit 5 epsilon.
   
 0.999
eif2b4
Eukaryotic translation initiation factor 2B, subunit 4 delta; Belongs to the eIF-2B alpha/beta/delta subunits family.
  
0.999
eif2s3
Eukaryotic translation initiation factor 2 subunit 3; As a subunit of eukaryotic initiation factor 2 (eIF2), involved in the early steps of protein synthesis. In the presence of GTP, eIF2 forms a ternary complex with initiator tRNA Met-tRNAi and then recruits the 40S ribosomal complex, a step that determines the rate of protein translation. This step is followed by mRNA binding to form the 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In o [...]
   
 0.983
eif2s2
Eukaryotic translation initiation factor 2, subunit 2 beta.
   
 0.976
opn3
Teleost encephalopsin/panopsin.
    
   0.946
eif2s1b
Eukaryotic translation initiation factor 2, subunit 1 alpha b.
   
 0.942
uba52
Ubiquitin A-52 residue ribosomal protein fusion product 1.
   
   0.935
EIF2AK4
Eukaryotic translation initiation factor 2 alpha kinase 4.
   
 
 0.917
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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