Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
smg5SMG5 nonsense mediated mRNA decay factor. (1099 aa)    
Predicted Functional Partners:
upf1
UPF1 RNA helicase and ATPase.
   
 0.999
upf3b
UPF3B regulator of nonsense mediated mRNA decay.
   
 0.996
smg1
SMG1 homolog phosphatidylinositol 3-kinase-related kinase (C. elegans); Belongs to the PI3/PI4-kinase family.
   
 0.995
upf2
Uncharacterized protein.
   
 
 0.995
upf3a
Regulator of nonsense transcripts 3A; Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. Binds spliced mRNA upstream of exon-exon junctions (By similarity); Belongs to the RENT3 family.
   
 0.992
smg9
SMG9 nonsense mediated mRNA decay factor.
   
 
 0.991
smg7
SMG7 nonsense mediated mRNA decay factor.
   
0.991
smg8
SMG8 nonsense mediated mRNA decay factor.
     
 0.990
smg6
SMG6 nonsense mediated mRNA decay factor.
   
0.988
xrn1
5'-3' exoribonuclease 1.
   
 
 0.951
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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