Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-expression
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[Homology]
Score
tnfaip1Tumor necrosis factor, alpha-induced protein 1 (endothelial). (320 aa)    
Predicted Functional Partners:
ubxn7
UBX domain protein 7.
    
 
 0.893
ubxn1
UBX domain-containing protein 1; Ubiquitin-binding protein that specifically binds 'Lys-6'- linked polyubiquitin chains. Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol. Involved in ubiquitin-proteasome systems (By similarity).
   
 
 0.873
cul3a
Cullin 3a; Belongs to the cullin family.
    
 
 0.802
cul3b
Cullin 3b; Belongs to the cullin family.
    
 
 0.802
rnd3a
Rho family GTPase 3a.
    
 0.792
zbtb47a
Zinc finger and BTB domain-containing 47a.
    
 
 0.775
rnd2
Rho family GTPase 2.
    
 0.749
faf1
Fas (TNFRSF6)-associated factor 1.
    
 
 0.743
kctd9b
Potassium channel tetramerization domain-containing 9b.
      
 0.720
ubxn2a
UBX domain protein 2A.
      
 0.681
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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