Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
dcun1d2bDCN1, defective in cullin neddylation 1, domain-containing 2b. (204 aa)    
Predicted Functional Partners:
rbx1
Ring-box 1, E3 ubiquitin protein ligase.
    
 
 0.829
cul2
Cullin 2; Belongs to the cullin family.
   
 
 0.782
cul1a
Cullin 1a; Belongs to the cullin family.
   
 
 0.761
cul1b
Cullin 1b; Belongs to the cullin family.
   
 
 0.761
ube2f
NEDD8-conjugating enzyme UBE2F; Accepts the ubiquitin-like protein NEDD8 from the uba3-nae1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase rbx2, but not rbx1, suggests that the rbx2-ube2f complex neddylates specific target proteins, such as cul5; Belongs to the ubiquitin-conjugating enzyme family. UBE2F subfamily.
    
 
 0.746
UBE2M
Si:ch1073-205c8.3; Belongs to the ubiquitin-conjugating enzyme family.
    
 
 0.746
cul5a
Cullin 5a; Belongs to the cullin family.
   
 
 0.708
cul5b
Cullin 5b; Belongs to the cullin family.
   
 
 0.708
cul3a
Cullin 3a; Belongs to the cullin family.
   
 
 0.690
cul3b
Cullin 3b; Belongs to the cullin family.
   
 
 0.690
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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