Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
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wdr83WD repeat domain-containing protein 83; Molecular scaffold protein for various multimeric protein complexes. Acts as a module in the assembly of a multicomponent scaffold for the ERK pathway, linking ERK responses to specific agonists. Also involved in response to hypoxia by acting as a negative regulator of HIF1A/HIF-1-alpha (By similarity); Belongs to the WD repeat MORG1 family. (315 aa)    
Predicted Functional Partners:
gpatch1
G patch domain-containing 1.
    
 
 0.978
bud31
Protein BUD31 homolog; Involved in pre-mRNA splicing process.
   
 
 0.977
sf3b4
Splicing factor 3b, subunit 4.
    
 
 0.977
prpf8
Pre-mRNA-processing factor 8.
    
 
 0.971
aqr
Aquarius intron-binding spliceosomal factor.
    
 
 0.968
ppil1
Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.
    
   0.946
DHX35
Zgc:158828.
   
 
 0.944
syf2
Pre-mRNA-splicing factor syf2; Involved in pre-mRNA splicing as component of the spliceosome.
    
   0.940
xab2
Similar to Xab2 protein.
    
   0.937
crnkl1
Crooked neck pre-mRNA-splicing factor 1.
    
   0.932
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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