Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
F1QS94_DANRESi:dkey-221h15.4; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (350 aa)    
Predicted Functional Partners:
cyp26a1
Cytochrome P450 26A1; A cytochrome P450 monooxygenase involved in the metabolism of all-trans retinoic acid (atRA), a signaling molecule that binds to retinoic acid receptors and regulates gene transcription. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds of atRA primarily at C-4. Has no activity toward 9-cis and 13-cis retinoic acid stereoisomer [...]
   
 
 0.895
lratb.2
Lecithin retinol acyltransferase b, tandem duplicate 2.
   
 
 0.886
dgat1a
O-acyltransferase.
     
 0.884
bco1l
Beta-carotene oxygenase 1,-like.
     
 0.878
bco1
Beta-carotene oxygenase 1.
     
 0.878
pnpla4
Patatin-like phospholipase domain-containing 4.
     
 0.877
aldh1a2
Aldehyde dehydrogenase 1 family, member A2; Belongs to the aldehyde dehydrogenase family.
  
  0.876
cyp27c1
Cytochrome P450 27C1; Efficiently catalyzes the conversion of all-trans retinol (also called vitamin A1, the precursor of 11-cis retinal) to 3,4- didehydroretinol (also called vitamin A2, the precursor of 11-cis 3,4- didehydroretinal). Also acts on all-trans retinal and all-trans retinoic acid. The replacement of 11-cis retinal chromophore in photopigments with 11-cis 3,4-didehydroretinal enhances sensitivity to long-wavelength light. This may improve vision in fresh water which is often turbid; Belongs to the cytochrome P450 family.
   
 
  0.873
sdr16c5b
Short chain dehydrogenase/reductase family 16C, member 5b; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
     
  0.871
lratb.1
Lecithin retinol acyltransferase b, tandem duplicate 1.
    
  0.871
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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