Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
cilp2Cartilage intermediate layer protein 2. (1255 aa)    
Predicted Functional Partners:
mef2b
Myocyte enhancer factor 2B.
      
 0.688
fitm1
Fat storage-inducing transmembrane protein 1; Plays an important role in lipid droplet accumulation. Belongs to the FIT family.
      
 0.686
scly
Selenocysteine lyase.
      
 0.676
rfxank
Regulatory factor X-associated ankyrin-containing protein.
    
 
 0.633
tnxba
Tenascin XBa.
   
 
 0.606
mtbp
MDM2-binding protein.
      
 0.606
rab6ba
RAB6B, member RAS oncogene family a.
      
 0.506
fgfbp2a
Fibroblast growth factor-binding protein 2a.
      
 0.504
pnpla3
Patatin-like phospholipase domain-containing 3.
      
 0.501
htra1b
Serine protease HTRA1B; Serine protease with a variety of targets, including extracellular matrix proteins and proteoglycans. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF- beta family members. Consequently, may regulate many physiological processes. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets ( [...]
   
  
 0.492
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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