Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
brk1Probable protein BRICK1; Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex (By similarity); Belongs to the BRK1 family. (83 aa)    
Predicted Functional Partners:
cyfip1
Cytoplasmic FMR1-interacting protein 1 homolog; Involved in formation of membrane ruffles and lamellipodia protrusions and in axon outgrowth. Binds to F-actin but not to RNA (By similarity); Belongs to the CYFIP family.
    
 0.999
NCKAP1L
Zgc:172352.
    
 0.999
wasf2
WASP family member 2.
    
 0.999
cyfip2
Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family.
    
 0.999
wasf1
WASP family member 1.
    
 0.999
nckap1
Nck-associated protein 1; Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1 (By similarity).
    
 0.999
wasf3b
WASP family member 3b.
    
 0.998
wasf3a
WASP family member 3a.
    
 0.996
abi1a
Abl-interactor 1a.
    
 0.996
I3ITM8_DANRE
Si:ch73-362m14.4.
    
 0.996
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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