Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
pou3f3aPOU domain, class 3, transcription factor 3-A; Transcription factor that may play important roles in patterning the embryonic brain. (446 aa)    
Predicted Functional Partners:
irx3b
Iroquois homeobox 3b.
      
 0.792
hnf1bb
Hepatocyte nuclear factor 1-beta-B; Transcription factor, probably binds to the inverted palindrome 5'-GTTAATNATTAAC-3' (By similarity). Acts downstream of hnf1ba but is not required for induction of rhombomere r5/r6 gene expression in the hindbrain.
   
  
 0.764
grhl2a
Grainyhead-like transcription factor 2a.
    
 
 0.658
sox21b
Transcription factor Sox-21-B; Acts as a negative regulator of transcription.
   
 
 0.599
mecom
MDS1 and EVI1 complex locus.
    
 
 0.599
slc4a4a
Anion exchange protein.
      
 0.567
dlx4a
Homeobox protein Dlx4a.
   
 
 0.566
hnf1ba
Hepatocyte nuclear factor 1-beta-A; Transcription factor, probably binds to the inverted palindrome 5'-GTTAATNATTAAC-3' (By similarity). Required for induction of rhombomere r5/r6 gene expression in the hindbrain.
      
 0.565
sox19a
Transcription factor Sox-19a; Transcriptional activator.
   
 
 0.554
sox19b
Transcription factor Sox-19b; Transcriptional activator.
   
 
 0.522
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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