Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
si:dkey-97o5.1Uncharacterized protein C1orf112 homolog. (911 aa)    
Predicted Functional Partners:
fignl1
Fidgetin-like 1; Belongs to the AAA ATPase family.
   
 0.958
plk1
Serine/threonine-protein kinase PLK.
   
 
  0.902
ppp1cc
Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family.
     
  0.900
snrnp48
Small nuclear ribonucleoprotein 48 (U11/U12).
      
 0.699
parpbp
PCNA-interacting partner; Required to suppress inappropriate homologous recombination, thereby playing a central role DNA repair and in the maintenance of genomic stability; Belongs to the PARI family.
   
  
 0.662
rad51
DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...]
   
 0.646
zgc:162698
Zgc:162698.
      
 0.639
brca2
BRCA2 DNA repair-associated.
   
 
 0.625
zgc:136864
UPF0390 protein zgc136864; Belongs to the UPF0390 family.
      
 0.617
lyar
Ly1 antibody reactive homolog (mouse).
      
 0.607
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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