Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
hsd11b1laHydroxysteroid 11-beta-dehydrogenase 1-like protein. (287 aa)    
Predicted Functional Partners:
hsd11b2
Hydroxysteroid (11-beta) dehydrogenase 2.
   
 
0.977
hsd11b1lb
Hydroxysteroid (11-beta) dehydrogenase 1-like b.
  
  
 
0.974
cyp17a1
Cytochrome P450, family 17, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family.
   
 
 0.973
cyp11c1
Cytochrome P450, family 11, subfamily C, polypeptide 1; Belongs to the cytochrome P450 family.
   
 
 0.972
cyp17a2
Cytochrome P450, family 17, subfamily A, polypeptide 2; Belongs to the cytochrome P450 family.
   
 
 0.967
hsd17b8
FabG (Beta-ketoacyl-[acyl-carrier-protein] reductase, E. coli) like.
  
  
 0.965
hsd20b2
20beta-hydroxysteroid dehydrogenase type 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
 
 
0.955
hsd17b12a
Very-long-chain 3-oxoacyl-CoA reductase-A; Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3- hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of memb [...]
 
 
0.953
hsd17b7
Hydroxysteroid (17-beta) dehydrogenase 7.
     
 0.951
dhrs11a
Dehydrogenase/reductase (SDR family) member 11a; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
     
  0.950
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.