Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
mier3bMesoderm induction early response 1, family member 3 b. (537 aa)    
Predicted Functional Partners:
ms4a17a.2
Membrane-spanning 4-domains, subfamily A, member 17a.2.
      
 0.800
kcnh6b
Potassium voltage-gated channel, subfamily H (eag-related), member 6b.
      
 0.800
ms4a17a.9
Membrane-spanning 4-domains, subfamily A, member 17A.9.
      
 0.800
arhgef3l
Rho guanine nucleotide exchange factor (GEF) 3,-like.
      
 0.798
papss2a
3'-phosphoadenosine 5'-phosphosulfate synthase 2a.
      
 0.795
tnni4b.1
Troponin I4b, tandem duplicate 1.
      
 0.779
nectin4b
Nectin cell adhesion molecule 4b.
      
 0.754
ms4a17a.8
Membrane-spanning 4-domains, subfamily A, member 17A.8.
      
 0.740
KYAT3
Si:ch73-97h19.2.
      
 0.739
smyd2b
N-lysine methyltransferase SMYD2-B; Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically trimethylates histone H3 'Lys-4' (H3K4me3) in vivo. The activity requires interaction with HSP90alpha. Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'.
   
 
 0.727
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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