Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
nr1h4Nuclear receptor subfamily 1, group H, member 4. (483 aa)    
Predicted Functional Partners:
gpbar1
G protein-coupled bile acid receptor 1.
      
 0.927
fgf19
Fibroblast growth factor; Belongs to the heparin-binding growth factors family.
    
 
 0.874
cyp7a1
Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family.
   
 0.862
ppargc1a
Peroxisome proliferator-activated receptor gamma, coactivator 1 alpha.
    
 0.827
abcb11b
ATP-binding cassette, sub-family B (MDR/TAP), member 11b.
   
 
 0.814
cyp8b1
Cytochrome P450, family 8, subfamily B, polypeptide 1.
   
 0.813
abcb11a
ATP-binding cassette, sub-family B (MDR/TAP), member 11a.
   
 
 0.795
ahr1b
Aryl hydrocarbon receptor 1B.
   
 
 0.775
rxraa
Retinoic acid receptor RXR-alpha-A; Receptor for retinoic acid that acts as a transcription factor. Forms homo- or heterodimers with retinoic acid receptors (rars) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes. The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 to regulate transcription. The high affinity ligand for rxrs is 9-cis retinoic acid. In the absence of ligand, the rar/rxr heterodimer [...]
   
0.775
ncoa1
Nuclear receptor coactivator 1.
    
 0.769
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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