node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
LOC569566 | fgf16 | ENSDARP00000117523 | ENSDARP00000061927 | Fibroblast growth factor receptor 1b,-like. | Fibroblast growth factor 16; Plays a crucial role in pectoral fin bud outgrowth. Belongs to the heparin-binding growth factors family. | 0.826 |
LOC569566 | fgf23 | ENSDARP00000117523 | ENSDARP00000067387 | Fibroblast growth factor receptor 1b,-like. | Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. | 0.821 |
LOC569566 | fgfr1a | ENSDARP00000117523 | ENSDARP00000013742 | Fibroblast growth factor receptor 1b,-like. | Fibroblast growth factor receptor 1-A; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and normal skeletogenesis. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. Phosphorylation of FRS2 triggers [...] | 0.900 |
LOC569566 | fgfr1b | ENSDARP00000117523 | ENSDARP00000069743 | Fibroblast growth factor receptor 1b,-like. | Fibroblast growth factor receptor. | 0.900 |
fgf16 | LOC569566 | ENSDARP00000061927 | ENSDARP00000117523 | Fibroblast growth factor 16; Plays a crucial role in pectoral fin bud outgrowth. Belongs to the heparin-binding growth factors family. | Fibroblast growth factor receptor 1b,-like. | 0.826 |
fgf16 | fgf23 | ENSDARP00000061927 | ENSDARP00000067387 | Fibroblast growth factor 16; Plays a crucial role in pectoral fin bud outgrowth. Belongs to the heparin-binding growth factors family. | Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. | 0.806 |
fgf16 | fgfr1a | ENSDARP00000061927 | ENSDARP00000013742 | Fibroblast growth factor 16; Plays a crucial role in pectoral fin bud outgrowth. Belongs to the heparin-binding growth factors family. | Fibroblast growth factor receptor 1-A; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and normal skeletogenesis. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. Phosphorylation of FRS2 triggers [...] | 0.921 |
fgf16 | fgfr1b | ENSDARP00000061927 | ENSDARP00000069743 | Fibroblast growth factor 16; Plays a crucial role in pectoral fin bud outgrowth. Belongs to the heparin-binding growth factors family. | Fibroblast growth factor receptor. | 0.869 |
fgf16 | fgfr2 | ENSDARP00000061927 | ENSDARP00000124472 | Fibroblast growth factor 16; Plays a crucial role in pectoral fin bud outgrowth. Belongs to the heparin-binding growth factors family. | Fibroblast growth factor receptor 2; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in kerati [...] | 0.916 |
fgf16 | fgfr3 | ENSDARP00000061927 | ENSDARP00000011898 | Fibroblast growth factor 16; Plays a crucial role in pectoral fin bud outgrowth. Belongs to the heparin-binding growth factors family. | Fibroblast growth factor receptor 3; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Phosphorylates PLCG1, CBL and FRS2. Ligand binding l [...] | 0.934 |
fgf16 | fgfr4 | ENSDARP00000061927 | ENSDARP00000143805 | Fibroblast growth factor 16; Plays a crucial role in pectoral fin bud outgrowth. Belongs to the heparin-binding growth factors family. | Fibroblast growth factor receptor 4; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down- regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation o [...] | 0.906 |
fgf16 | flt3 | ENSDARP00000061927 | ENSDARP00000075800 | Fibroblast growth factor 16; Plays a crucial role in pectoral fin bud outgrowth. Belongs to the heparin-binding growth factors family. | Fms-related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. | 0.737 |
fgf16 | pdgfra | ENSDARP00000061927 | ENSDARP00000094286 | Fibroblast growth factor 16; Plays a crucial role in pectoral fin bud outgrowth. Belongs to the heparin-binding growth factors family. | Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for pdgfa, pdgfb and pdgfc and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. Required for normal development of the gastrointestinal tract. Plays a role in cell migration and chemotaxis in wound [...] | 0.758 |
fgf16 | pdgfrb | ENSDARP00000061927 | ENSDARP00000152459 | Fibroblast growth factor 16; Plays a crucial role in pectoral fin bud outgrowth. Belongs to the heparin-binding growth factors family. | Platelet-derived growth factor receptor, beta polypeptide; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. | 0.738 |
fgf23 | LOC569566 | ENSDARP00000067387 | ENSDARP00000117523 | Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. | Fibroblast growth factor receptor 1b,-like. | 0.821 |
fgf23 | fgf16 | ENSDARP00000067387 | ENSDARP00000061927 | Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. | Fibroblast growth factor 16; Plays a crucial role in pectoral fin bud outgrowth. Belongs to the heparin-binding growth factors family. | 0.806 |
fgf23 | fgfr1a | ENSDARP00000067387 | ENSDARP00000013742 | Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. | Fibroblast growth factor receptor 1-A; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and normal skeletogenesis. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. Phosphorylation of FRS2 triggers [...] | 0.975 |
fgf23 | fgfr1b | ENSDARP00000067387 | ENSDARP00000069743 | Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. | Fibroblast growth factor receptor. | 0.869 |
fgf23 | fgfr2 | ENSDARP00000067387 | ENSDARP00000124472 | Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. | Fibroblast growth factor receptor 2; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in kerati [...] | 0.914 |
fgf23 | fgfr3 | ENSDARP00000067387 | ENSDARP00000011898 | Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. | Fibroblast growth factor receptor 3; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Phosphorylates PLCG1, CBL and FRS2. Ligand binding l [...] | 0.915 |