Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
ccdc88cProtein Daple; Positive regulator of Wnt signaling, acting synergistically with dvl2 (By similarity). Functions upstream of ctnnb1/beta-catenin in the canonical Wnt pathway, and also activates jnk in the Wnt/planar cell polarity (PCP) pathway (By similarity). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein G(i) alpha (Gi-alpha) subunits. This promotes apical cell constriction and subsequent bending of the neural plate during neurulation via arhgef18 (By similarity). (1997 aa)    
Predicted Functional Partners:
ap1s2
AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.
      
 0.714
AP1S2
AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.
      
 0.714
patj
PATJ crumbs cell polarity complex component.
    
 
 0.682
ENSDARP00000131526
Si:dkey-92j12.5.
    
 
 0.681
cep350
Centrosomal protein 350.
   
 
 0.653
cep89
Centrosomal protein of 89 kDa; Required for ciliogenesis. Also plays a role in mitochondrial metabolism where it may modulate complex IV activity (By similarity).
    
   0.560
akna
AT-hook transcription factor.
      
 0.560
tcf25
Transcription factor 25 (basic helix-loop-helix).
      
 0.547
btbd7
BTB (POZ) domain-containing 7.
      
 0.527
bicd2
Bicaudal D homolog 2 (Drosophila).
    
 
 0.526
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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