Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
actc1aActin, alpha, cardiac muscle 1a. (377 aa)    
Predicted Functional Partners:
actc1c
Actin alpha cardiac muscle 1a.
  
 
0.966
tnnt2a
Troponin T type 2a (cardiac).
   
 0.929
actc1b
Actin, alpha 1, skeletal muscle.
  
 
0.925
acta1b
Actin alpha 1, skeletal muscle b.
  
 
0.923
zgc:86709
Novel actin protein.
  
 
0.922
ENSDARP00000100434
Actin alpha cardiac muscle 1a.
  
  
0.922
acta1a
Actin alpha 1, skeletal muscle a.
  
 
0.914
acta2
Actin, alpha 2, smooth muscle, aorta.
  
 
0.910
tnnt2e
Novel slow skeletal troponin T family protein.
   
  0.898
tpm4a
Tropomyosin 4a; Belongs to the tropomyosin family.
   
 0.882
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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