node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PDCL3 | pdcb | ENSDARP00000135403 | ENSDARP00000062538 | Phosducin-like protein 3; Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, increasing its abundance by inhibiting its ubiquitination and degradation. Inhibits the folding activity of the chaperonin-containing T-complex (CCT) which leads to inhibition of cytoskeletal actin folding (By similarity). Acts as a chaperone during heat shock alongside HSP90 and HSP40/70 chaperone complexes (By similarity). Modulates the activation of caspases during apoptosis (By similarity). | Phosducin b. | 0.655 |
gnb5a | gngt1 | ENSDARP00000140306 | ENSDARP00000051949 | Guanine nucleotide-binding protein subunit beta-5a; Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (Probable). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors (By similarity). Along with gnb5b, plays an important role in neuronal [...] | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | 0.837 |
gnb5a | pdcb | ENSDARP00000140306 | ENSDARP00000062538 | Guanine nucleotide-binding protein subunit beta-5a; Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (Probable). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors (By similarity). Along with gnb5b, plays an important role in neuronal [...] | Phosducin b. | 0.645 |
gnb5a | rho | ENSDARP00000140306 | ENSDARP00000011562 | Guanine nucleotide-binding protein subunit beta-5a; Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (Probable). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors (By similarity). Along with gnb5b, plays an important role in neuronal [...] | Rhodopsin; Photoreceptor required for image-forming vision at low light intensity. While most salt water fish species use retinal as chromophore, most freshwater fish use 3-dehydroretinal, or a mixture of retinal and 3-dehydroretinal (By similarity). Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by arrestin and terminates signaling (By similarity). | 0.684 |
gngt1 | gnb5a | ENSDARP00000051949 | ENSDARP00000140306 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | Guanine nucleotide-binding protein subunit beta-5a; Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (Probable). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors (By similarity). Along with gnb5b, plays an important role in neuronal [...] | 0.837 |
gngt1 | opn1mw1 | ENSDARP00000051949 | ENSDARP00000001158 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | Green-sensitive opsin-1; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. | 0.809 |
gngt1 | opn1mw2 | ENSDARP00000051949 | ENSDARP00000011837 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | Green-sensitive opsin-2; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal; Belongs to the G-protein coupled receptor 1 family. Opsin subfamily. | 0.854 |
gngt1 | pdcb | ENSDARP00000051949 | ENSDARP00000062538 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | Phosducin b. | 0.708 |
gngt1 | prph2a | ENSDARP00000051949 | ENSDARP00000055414 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | Peripherin 2a (retinal degeneration, slow). | 0.502 |
gngt1 | prph2b | ENSDARP00000051949 | ENSDARP00000011326 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | Peripherin 2b (retinal degeneration, slow). | 0.515 |
gngt1 | rho | ENSDARP00000051949 | ENSDARP00000011562 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | Rhodopsin; Photoreceptor required for image-forming vision at low light intensity. While most salt water fish species use retinal as chromophore, most freshwater fish use 3-dehydroretinal, or a mixture of retinal and 3-dehydroretinal (By similarity). Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by arrestin and terminates signaling (By similarity). | 0.883 |
opn1mw1 | gngt1 | ENSDARP00000001158 | ENSDARP00000051949 | Green-sensitive opsin-1; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | 0.809 |
opn1mw1 | pdcb | ENSDARP00000001158 | ENSDARP00000062538 | Green-sensitive opsin-1; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. | Phosducin b. | 0.655 |
opn1mw1 | prph2a | ENSDARP00000001158 | ENSDARP00000055414 | Green-sensitive opsin-1; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. | Peripherin 2a (retinal degeneration, slow). | 0.803 |
opn1mw1 | prph2b | ENSDARP00000001158 | ENSDARP00000011326 | Green-sensitive opsin-1; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. | Peripherin 2b (retinal degeneration, slow). | 0.796 |
opn1mw1 | prph2la | ENSDARP00000001158 | ENSDARP00000146956 | Green-sensitive opsin-1; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. | Peripherin 2-like a. | 0.736 |
opn1mw1 | prph2lb | ENSDARP00000001158 | ENSDARP00000002686 | Green-sensitive opsin-1; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. | Si:dkey-85n7.2 protein. | 0.765 |
opn1mw2 | gngt1 | ENSDARP00000011837 | ENSDARP00000051949 | Green-sensitive opsin-2; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal; Belongs to the G-protein coupled receptor 1 family. Opsin subfamily. | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | 0.854 |
opn1mw2 | pdcb | ENSDARP00000011837 | ENSDARP00000062538 | Green-sensitive opsin-2; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal; Belongs to the G-protein coupled receptor 1 family. Opsin subfamily. | Phosducin b. | 0.673 |
opn1mw2 | prph2a | ENSDARP00000011837 | ENSDARP00000055414 | Green-sensitive opsin-2; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal; Belongs to the G-protein coupled receptor 1 family. Opsin subfamily. | Peripherin 2a (retinal degeneration, slow). | 0.834 |