Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
blnkB cell linker. (490 aa)    
Predicted Functional Partners:
grb2b
Growth factor receptor-bound protein 2b.
    
 0.987
grb2a
Growth factor receptor-bound protein 2a.
    
 0.987
syk
Tyrosine-protein kinase.
   
 0.983
cd79a
CD79a molecule, immunoglobulin-associated alpha.
   
 
 0.975
zap70
Tyrosine-protein kinase.
   
 0.960
btk
Tyrosine-protein kinase.
   
 0.959
itk
Tyrosine-protein kinase.
   
 0.925
lcp2a
Lymphocyte cytosolic protein 2a.
  
0.919
tec
Tyrosine-protein kinase.
   
 0.877
plcg2
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.
   
 0.875
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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