Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
itsn2aIntersectin 2a. (1665 aa)    
Predicted Functional Partners:
fcho1
F-BAR domain only protein 1.
   
 
 0.987
synj1
Synaptojanin 1.
   
 
 0.978
ap2s1
AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.
   
 
 0.955
ap2m1b
AP-2 complex subunit mu-B; Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. AP50 is a subunit of the plasma membrane adaptor. The complex binds polyphosphoinositide- containing lipids (By similarity).
    
 
 0.953
ap2m1a
AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]
    
 
 0.953
necap1
NECAP endocytosis-associated 1.
   
 
 0.927
ap4b1
AP complex subunit beta; Belongs to the adaptor complexes large subunit family.
    
 
 0.908
ap1b1
AP complex subunit beta.
    
 
 0.908
ap2b1
AP complex subunit beta.
    
 
 0.908
eps15
Epidermal growth factor receptor pathway substrate 15.
   
 
0.899
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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