node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EIF2AK4 | eif2ak3 | ENSDARP00000137378 | ENSDARP00000120826 | Eukaryotic translation initiation factor 2 alpha kinase 4. | Eukaryotic translation initiation factor 2-alpha kinase 3. | 0.414 |
EIF2AK4 | nfe2l2a | ENSDARP00000137378 | ENSDARP00000062853 | Eukaryotic translation initiation factor 2 alpha kinase 4. | Nuclear factor (Erythroid-derived 2)-like 2. | 0.907 |
cul3a | cul3b | ENSDARP00000056881 | ENSDARP00000132246 | Cullin 3a; Belongs to the cullin family. | Cullin 3b; Belongs to the cullin family. | 0.900 |
cul3a | hmox1a | ENSDARP00000056881 | ENSDARP00000038993 | Cullin 3a; Belongs to the cullin family. | Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. | 0.608 |
cul3a | keap1a | ENSDARP00000056881 | ENSDARP00000045762 | Cullin 3a; Belongs to the cullin family. | Kelch-like ECH-associated protein 1A; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting nfe2l2/nrf2 for ubiquitination. Keap1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of nfe2l2/nrf2, a transcription factor regulating expression of many cytoprotective genes. In response to oxidative stress, different electrophile metabolites trigger non- enzymatic covalent modifications of highly reactive cystei [...] | 0.996 |
cul3a | keap1b | ENSDARP00000056881 | ENSDARP00000124228 | Cullin 3a; Belongs to the cullin family. | Kelch-like ECH-associated protein 1B; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting nfe2l2/nrf2 for ubiquitination. Keap1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of nfe2l2/nrf2, a transcription factor regulating expression of many cytoprotective genes. In response to oxidative stress, different electrophile metabolites trigger non- enzymatic covalent modifications of highly reactive cystei [...] | 0.849 |
cul3a | mafk | ENSDARP00000056881 | ENSDARP00000140698 | Cullin 3a; Belongs to the cullin family. | V-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K. | 0.435 |
cul3a | nfe2l2a | ENSDARP00000056881 | ENSDARP00000062853 | Cullin 3a; Belongs to the cullin family. | Nuclear factor (Erythroid-derived 2)-like 2. | 0.904 |
cul3b | cul3a | ENSDARP00000132246 | ENSDARP00000056881 | Cullin 3b; Belongs to the cullin family. | Cullin 3a; Belongs to the cullin family. | 0.900 |
cul3b | hmox1a | ENSDARP00000132246 | ENSDARP00000038993 | Cullin 3b; Belongs to the cullin family. | Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. | 0.609 |
cul3b | keap1a | ENSDARP00000132246 | ENSDARP00000045762 | Cullin 3b; Belongs to the cullin family. | Kelch-like ECH-associated protein 1A; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting nfe2l2/nrf2 for ubiquitination. Keap1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of nfe2l2/nrf2, a transcription factor regulating expression of many cytoprotective genes. In response to oxidative stress, different electrophile metabolites trigger non- enzymatic covalent modifications of highly reactive cystei [...] | 0.996 |
cul3b | keap1b | ENSDARP00000132246 | ENSDARP00000124228 | Cullin 3b; Belongs to the cullin family. | Kelch-like ECH-associated protein 1B; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting nfe2l2/nrf2 for ubiquitination. Keap1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of nfe2l2/nrf2, a transcription factor regulating expression of many cytoprotective genes. In response to oxidative stress, different electrophile metabolites trigger non- enzymatic covalent modifications of highly reactive cystei [...] | 0.952 |
cul3b | mafk | ENSDARP00000132246 | ENSDARP00000140698 | Cullin 3b; Belongs to the cullin family. | V-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K. | 0.436 |
cul3b | nfe2l2a | ENSDARP00000132246 | ENSDARP00000062853 | Cullin 3b; Belongs to the cullin family. | Nuclear factor (Erythroid-derived 2)-like 2. | 0.949 |
ddit3 | eif2ak3 | ENSDARP00000078063 | ENSDARP00000120826 | DNA-damage-inducible transcript 3. | Eukaryotic translation initiation factor 2-alpha kinase 3. | 0.616 |
ddit3 | nfe2l2a | ENSDARP00000078063 | ENSDARP00000062853 | DNA-damage-inducible transcript 3. | Nuclear factor (Erythroid-derived 2)-like 2. | 0.923 |
eif2ak2 | nfe2l2a | ENSDARP00000133369 | ENSDARP00000062853 | Eukaryotic translation initiation factor 2-alpha kinase 2. | Nuclear factor (Erythroid-derived 2)-like 2. | 0.922 |
eif2ak3 | EIF2AK4 | ENSDARP00000120826 | ENSDARP00000137378 | Eukaryotic translation initiation factor 2-alpha kinase 3. | Eukaryotic translation initiation factor 2 alpha kinase 4. | 0.414 |
eif2ak3 | ddit3 | ENSDARP00000120826 | ENSDARP00000078063 | Eukaryotic translation initiation factor 2-alpha kinase 3. | DNA-damage-inducible transcript 3. | 0.616 |
eif2ak3 | nfe2l2a | ENSDARP00000120826 | ENSDARP00000062853 | Eukaryotic translation initiation factor 2-alpha kinase 3. | Nuclear factor (Erythroid-derived 2)-like 2. | 0.949 |