Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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Score
rnf169E3 ubiquitin-protein ligase RNF169; Probable E3 ubiquitin-protein ligase that acts as a negative regulator of double-strand breaks (DSBs) repair following DNA damage. (630 aa)    
Predicted Functional Partners:
usp7
Ubiquitin-specific peptidase 7 (herpes virus-associated); Belongs to the peptidase C19 family.
    
 
 0.951
dcaf7
Ddb1 and cul4-associated factor 7.
   
 
 0.945
dyrk1b
Dual-specificity tyrosine-(Y)-phosphorylation-regulated kinase 1B.
   
 
 0.886
tp53bp1
Tumor protein p53-binding protein, 1.
    
 
 0.872
rad18
RAD18 E3 ubiquitin protein ligase.
   
  
 0.832
rnf168
E3 ubiquitin-protein ligase rnf168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with ube2n/ubc13 to amplify the rnf8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the rnf8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...]
    
 
0.831
FAM53C
LOC100002393 protein.
      
 0.830
rnf8
E3 ubiquitin-protein ligase rnf8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated mdc1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of tp53 [...]
      
 0.826
uba52
Ubiquitin A-52 residue ribosomal protein fusion product 1.
   
 
 0.798
dyrk1aa
Dual-specificity tyrosine-(Y)-phosphorylation-regulated kinase 1A, a.
   
 
 0.792
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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