Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-expression
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[Homology]
Score
sesn1Sestrin 1. (488 aa)    
Predicted Functional Partners:
mios
GATOR complex protein MIOS; As a component of the GATOR complex may function in the amino acid-sensing branch of the TORC1 signaling pathway.
    
 0.980
wdr24
GATOR complex protein WDR24; As a component of the GATOR complex may function in the amino acid-sensing branch of the TORC1 signaling pathway.
    
 0.979
seh1l
Nucleoporin SEH1; Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. This subunit plays a role in recruitment of the Nup107-160 subcomplex to the kinetochore. Belongs to the WD repeat SEC13 family.
    
 0.972
wdr59
WD repeat domain 59.
    
 0.969
sec13
SEC13 homolog, nuclear pore and COPII coat complex component; Belongs to the WD repeat SEC13 family.
    
 0.943
E7F0F7_DANRE
Si:zfos-80g12.1.
     
  0.934
sesn3
Sestrin 3.
     
  0.877
castor1
Cytosolic arginine sensor for mTORC1 subunit 1.
    
 
 0.870
nprl3
NPR3-like, GATOR1 complex subunit.
    
 
 0.779
depdc5
DEP domain-containing 5, GATOR1 subcomplex subunit.
    
 
 0.710
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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