node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
cdk5r2a | mfng | ENSDARP00000104135 | ENSDARP00000063007 | Cyclin-dependent kinase 5 activator. | Beta-1,3-N-acetylglucosaminyltransferase manic fringe; Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. | 0.570 |
cdk5r2a | ptprna | ENSDARP00000104135 | ENSDARP00000075984 | Cyclin-dependent kinase 5 activator. | Protein tyrosine phosphatase receptor type Na. | 0.682 |
dll4 | lfng | ENSDARP00000094097 | ENSDARP00000031031 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. | Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe; Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Involved in the correct formation of boundaries in the somites and hindbrain (By similarity). Required for Delta-Notch-mediated induction of hypochord cells at the lateral borders of the midline precursor domain. | 0.536 |
dll4 | mfng | ENSDARP00000094097 | ENSDARP00000063007 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. | Beta-1,3-N-acetylglucosaminyltransferase manic fringe; Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. | 0.596 |
dll4 | notch1a | ENSDARP00000094097 | ENSDARP00000137942 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. | Neurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...] | 0.990 |
dll4 | notch1b | ENSDARP00000094097 | ENSDARP00000050854 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. | Notch receptor 1b. | 0.949 |
dll4 | notch2 | ENSDARP00000094097 | ENSDARP00000112112 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. | Notch receptor 2. | 0.924 |
dll4 | notch3 | ENSDARP00000094097 | ENSDARP00000068420 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. | Notch receptor 3. | 0.792 |
jag1a | lfng | ENSDARP00000121170 | ENSDARP00000031031 | Protein jagged-1a; Ligand for multiple Notch receptors and involved in the mediation of Notch signaling (By similarity). Seems to be involved in cell-fate decisions. | Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe; Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Involved in the correct formation of boundaries in the somites and hindbrain (By similarity). Required for Delta-Notch-mediated induction of hypochord cells at the lateral borders of the midline precursor domain. | 0.611 |
jag1a | mfng | ENSDARP00000121170 | ENSDARP00000063007 | Protein jagged-1a; Ligand for multiple Notch receptors and involved in the mediation of Notch signaling (By similarity). Seems to be involved in cell-fate decisions. | Beta-1,3-N-acetylglucosaminyltransferase manic fringe; Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. | 0.535 |
jag1a | notch1a | ENSDARP00000121170 | ENSDARP00000137942 | Protein jagged-1a; Ligand for multiple Notch receptors and involved in the mediation of Notch signaling (By similarity). Seems to be involved in cell-fate decisions. | Neurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...] | 0.999 |
jag1a | notch1b | ENSDARP00000121170 | ENSDARP00000050854 | Protein jagged-1a; Ligand for multiple Notch receptors and involved in the mediation of Notch signaling (By similarity). Seems to be involved in cell-fate decisions. | Notch receptor 1b. | 0.987 |
jag1a | notch2 | ENSDARP00000121170 | ENSDARP00000112112 | Protein jagged-1a; Ligand for multiple Notch receptors and involved in the mediation of Notch signaling (By similarity). Seems to be involved in cell-fate decisions. | Notch receptor 2. | 0.983 |
jag1a | notch3 | ENSDARP00000121170 | ENSDARP00000068420 | Protein jagged-1a; Ligand for multiple Notch receptors and involved in the mediation of Notch signaling (By similarity). Seems to be involved in cell-fate decisions. | Notch receptor 3. | 0.985 |
jag1a | rfng | ENSDARP00000121170 | ENSDARP00000105906 | Protein jagged-1a; Ligand for multiple Notch receptors and involved in the mediation of Notch signaling (By similarity). Seems to be involved in cell-fate decisions. | Beta-1,3-N-acetylglucosaminyltransferase radical fringe; Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules (By similarity). Regulates neurogenesis in the hindbrain; involved in boundary cell specification via Notch- mediated activation of wnt1 expression. | 0.502 |
lfng | dll4 | ENSDARP00000031031 | ENSDARP00000094097 | Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe; Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Involved in the correct formation of boundaries in the somites and hindbrain (By similarity). Required for Delta-Notch-mediated induction of hypochord cells at the lateral borders of the midline precursor domain. | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. | 0.536 |
lfng | jag1a | ENSDARP00000031031 | ENSDARP00000121170 | Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe; Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Involved in the correct formation of boundaries in the somites and hindbrain (By similarity). Required for Delta-Notch-mediated induction of hypochord cells at the lateral borders of the midline precursor domain. | Protein jagged-1a; Ligand for multiple Notch receptors and involved in the mediation of Notch signaling (By similarity). Seems to be involved in cell-fate decisions. | 0.611 |
lfng | mfng | ENSDARP00000031031 | ENSDARP00000063007 | Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe; Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Involved in the correct formation of boundaries in the somites and hindbrain (By similarity). Required for Delta-Notch-mediated induction of hypochord cells at the lateral borders of the midline precursor domain. | Beta-1,3-N-acetylglucosaminyltransferase manic fringe; Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. | 0.908 |
lfng | notch1a | ENSDARP00000031031 | ENSDARP00000137942 | Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe; Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Involved in the correct formation of boundaries in the somites and hindbrain (By similarity). Required for Delta-Notch-mediated induction of hypochord cells at the lateral borders of the midline precursor domain. | Neurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...] | 0.974 |
lfng | notch1b | ENSDARP00000031031 | ENSDARP00000050854 | Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe; Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Involved in the correct formation of boundaries in the somites and hindbrain (By similarity). Required for Delta-Notch-mediated induction of hypochord cells at the lateral borders of the midline precursor domain. | Notch receptor 1b. | 0.922 |