STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
adam17aADAM metallopeptidase domain 17a. (842 aa)    
Predicted Functional Partners:
notch1a
Neurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...]
    
 0.915
notch1b
Notch receptor 1b.
    
 0.904
notch3
Notch receptor 3.
    
 0.904
notch2
Notch receptor 2.
   
 0.904
adam17b
ADAM metallopeptidase domain 17b.
  
 
0.904
timp4.3
TIMP metallopeptidase inhibitor 4, tandem duplicate 3.
    
 
 0.858
ngfra
Nerve growth factor receptor a (TNFR superfamily, member 16).
     
 0.758
timp2a
Tissue inhibitor of metalloproteinase 2.
   
 
 0.565
timp2b
TIMP metallopeptidase inhibitor 2b.
   
 
 0.565
timp4.1
TIMP metallopeptidase inhibitor 4, tandem duplicate 1.
    
 
 0.563
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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