Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
cyp4f3Cytochrome P450, family 4, subfamily F, polypeptide 3; Belongs to the cytochrome P450 family. (313 aa)    
Predicted Functional Partners:
cyp3a65
Cytochrome P450, family 3, subfamily A, polypeptide 65; Belongs to the cytochrome P450 family.
  
0.919
lta4h
Leukotriene A(4) hydrolase; Belongs to the peptidase M1 family.
    
 0.913
cyp2u1
Cytochrome P450, family 2, subfamily U, polypeptide 1; Belongs to the cytochrome P450 family.
  
0.906
cyp26b1
Cytochrome P450 26B1; Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Appears to be involved in the inactivation of all-trans-retinoic acid (RA). Plays a role in skeletal development; Belongs to the cytochrome P450 family.
  
  
0.886
pla2g12b
Phospholipase A2, group XIIB.
   
 
 0.881
cyp26a1
Cytochrome P450 26A1; A cytochrome P450 monooxygenase involved in the metabolism of all-trans retinoic acid (atRA), a signaling molecule that binds to retinoic acid receptors and regulates gene transcription. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds of atRA primarily at C-4. Has no activity toward 9-cis and 13-cis retinoic acid stereoisomer [...]
  
  
0.880
ephx2
Epoxide hydrolase 2, cytoplasmic.
   
 0.874
pla2g1b
Phospholipase A(2).
     
 0.866
pla2g6
Phospholipase A2, group VI (cytosolic, calcium-independent).
     
 0.866
ptgs1
Prostaglandin-endoperoxide synthase 1.
     
 0.861
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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