Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ppm1eProtein phosphatase, Mg2+/Mn2+-dependent, 1E. (633 aa)    
Predicted Functional Partners:
fem1b
Fem-1 homolog b.
   
 
 0.767
fem1c
Protein fem-1 homolog C; Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit; Belongs to the fem-1 family.
   
 
 0.767
triob
Trio Rho guanine nucleotide exchange factor b.
    
 
 0.664
trioa
Triple functional domain protein; Promotes the exchange of GDP by GTP. Together with leukocyte antigen-related (LAR) protein, it could play a role in coordinating cell-matrix and cytoskeletal rearrangements necessary for cell migration and cell growth (By similarity); Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
    
 
 0.664
ENSDARP00000131526
Si:dkey-92j12.5.
      
 0.661
tmem134
Transmembrane protein 134.
      
 0.645
slc25a27
Solute carrier family 25 member 27; Belongs to the mitochondrial carrier (TC 2.A.29) family.
      
 0.645
rnf170
E3 ubiquitin-protein ligase RNF170; E3 ubiquitin-protein ligase that plays an essential role in stimulus-induced inositol 1,4,5-trisphosphate receptor (ITPR) ubiquitination and degradation via the endoplasmic reticulum-associated degradation (ERAD) pathway. Also involved in ITPR turnover in resting cells.
      
 0.645
mrps2
Mitochondrial ribosomal protein S2.
      
 0.639
tor2a
Torsin.
      
 0.607
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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